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TSEN2 Antibody

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Delivery term: The date of payment from buyers deliver within days
seat: Zhejiang
Validity to: Long-term effective
Last update: 2017-07-22 14:50
Browse the number: 261
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Product details
Product Name: TSEN2 Antibody
Code : CSB-PA850858DSR2HU
Size : 100μl:US$167   50μl:US$100
Uniprot NO. : Q8NCE0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Image :

Western blot            

All lanes:TSEN2 antibody at 5ug/ml+293T 

whole cell lysate

Secondary

Goat polyclonal to rabbit at 1/10000 dilution

Predicted band size :53kDa 

Observed band size :53kDa 



Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850858DSR2HU at dilution 1:100


Immunogen : Recombinant human tRNA-splicing endonuclease subunit Sen2 protein (1-220aa)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications: ELISA,WB,IHC;Recommended dilution:WB:1:200-1000,IHC:1:50-1:200
Relevance : Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5\'- and 3\'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2\',3\'-cyclic phosphate and 5\'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5\'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3\'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3\'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
Form : Liquid
Conjugate : Non-conjugated
Storage Buffer : PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification method : Antigen Affinity Purified
Isotype : IgG
Clonality : Polyclonal
Alias : tRNA-intron endonuclease Sen2,HsSen2,TSEN2,SEN2
Species : Human

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